Brand from Japan: LION. Contains active enzymes that break down and remove plaque that causes dental problems.This is the only medicated toothpaste in Japan that contains the active ingredient enzyme.It can break down and remove tartar that causes various risks in the oral cavity.Enzymes can break down and remove plaque in corners that a toothbrush cannot reach.In addition to teeth, it can also protect the health of gums and prevent periodontal disease.Contains high concentration of fluoride (1450ppm).Fluoride strengthens tooth structure and protects dental health.Kills disease-causing bacteria and prevents bad breath.Refreshing natural green mint flavorHow to use:Apply an appropriate amount to a toothbrush for use.